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Aiosyn

Atherosclerotic lesion analysisacross the aortic root

Aiosyn's AI-powered image analysis quantifies atherosclerotic lesion area across the full aortic-root cross-section of every animal in your cohort. Every read-out is returned as consistent, quantitative measurements, supporting the statistical power of preclinical studies.

Discuss your study
  • Fully measure every section
  • Consistent measurements across runs
  • Validated against expert pathologist scoring
Stained sectionAI read-out
Drag the handle. Left: stained aortic root. Right: segmentation overlay.
  • Atherosclerotic lesion
  • Vessel wall

Agreement with expert pathologist scoring

A method validation with TNO, not a published paper: an expert pathologist measured the lesion area on each mouse aortic-root cross-section, and the AI measured the same sections independently. The kidney work is the published one.

AI against expert pathologist

Lesion area, mouse aortic-root cross-section

Correlation
r = 0.96
Variance explained
R² = 0.91
Sections
80

Each point is one cross-section: the pathologist's lesion area on the horizontal axis, the AI's on the vertical, against the line of perfect agreement.

AI versus pathologist lesion area Scatter of 80 cases comparing Aiosyn AI lesion-area read-outs with expert pathologist scoring; points cluster along the line of perfect agreement (Pearson r = 0.96). 0 0 400 400 800 800 1200 1200 1600 1600 y = x r = 0.96 · R² = 0.91 · n = 80 Pathologist lesion area (×10³ µm²) AI lesion area (×10³ µm²)
Validated with TNO.

What comes back from every section

An aortic root is normally read by eye, from a few sections, onto a grading scale. Aiosyn delineates the atherosclerotic lesion and the vessel wall on every section in the cohort, and measures the lesion area from those delineations.

  • Lesion area per cross-section, in µm², measured across the full section rather than a sampled part of it.
  • The vessel wall delineated on the same section, so the lesion is measured against the wall it sits in.
  • The delineations themselves, so every figure traces back to the tissue it came from.

On mouse aortic roots

Our measurements are validated on mouse aortic-root cross-sections. For analysis on different vessels or species, check out our custom AI development.

  1. 1

    Share your data

    Whole-slide images of aortic root sections in your preferred format.

  2. 2

    Measure

    Automated analysis, allowing for a quick turnaround.

  3. 3

    Report

    A comprehensive report of our analysis is shared, including the raw data for further study.

Plaque composition

Lesion area answers how much. Composition answers what the lesion is made of.

We quantify composition on your sections as part of a scoped engagement, alongside the lesion area the standard suite returns.

Smooth muscle cells and macrophages are measured in MAC3, the necrotic core in HPS, and fibrous area in Picrosirius Red.

If composition is the endpoint your study turns on, tell us which components you need measured and we will tell you where the model stands on them.

Ask about composition

Co-developed with TNO Health & Work

Through our partnership, we co-develop these models together with TNO. Their preclinical and pharmaceutical research expertise sits behind the study design and the tissue, our AI behind the read-outs, and the models are applied within TNO's preclinical studies with more study areas in development.

Continue with another tissue

Biopharma overview

Put it on your own aortic roots

Send a handful of aortic-root sections and we will return the lesion areas on your own tissue, so you can judge the measurement before a study depends on it.