Publication
Quantitative Image Analysis Reveals the Benefits of Dapagliflozin on Glomerulosclerosis, Podocytes Effacement and Kidney Fibrosis in the SDT Fatty Rat Model of Diabetic Nephropathy
By Błażej Dolicki
26 October, 2024
Authors
François Briand, Estelle Grasset, Masami Shinohara, Nicole Endlich, Vedran Drenić, Li Chen, Mathieu Petitjean,
Blazej Dolicki, Thomas de Bel, Yasushi Kageyama, Thierry Sulpice
Abstract
We aimed to optimize drug efficacy studies in the Spontaneously Diabetic Torii (SDT) fatty rat, a type 2 diabetic model, using quantitative image analysis of kidney. To demonstrate the accuracy of our imaging methods, dapagliflozin (DAPA) was evaluated in SDT fatty rats with unilateral nephrectomy (Unx).
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