Publication
Quantitative Image Analysis Uncovers the Efficacy of the Selective Endothelin A Receptor Antagonist Atrasentan in a Rat Model of IgA Nephropathy
By Thomas de Bel
26 October, 2024
Authors
François Briand, Estelle Grasset, Nicole Endlich, VedranDrenić, Blazej Dolicki, Thomas de Bel, Thierry Sulpice
Abstract
Our aim was to validate and optimize a rat model of IgA nephropathy for drug efficacy studies using quantitative image analysis of kidney. To demonstrate the accuracy of our imaging methods, we evaluated atrasentan, a selective Endothelin A receptor Antagonist currently evaluated in phase III clinical trials.
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